DERIVATIVES OF 2-IMINOBENZOTHAZOLINES, THEIR ENANTIOMERS WITH ASYMMETRIC CENTER AND THEIR ACID-ADDITIVE PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

摘要

FIELD: organic chemistry. SUBSTANCE: products: derivatives of 2-iminobenzothiazolines of the formula (I) where R₁ - polyfluorine-C₁-C₄-alkyl or polyfluorine-C₁-C₄-alkoxy-group, R₂ a group of the formula CH₂[CH(R₄)]_n-R₃, where R₃-qu-(C₁-C₄)-alkylamino-group, 1-piperidinyl, 1-pyrrolidinyl, mercapto-group, C₁-C₄-acylthio-group, C₁-C₄-alkylthio-group, C₁-C₄-alkylsulfinyl- or C₁-C₄-alkylsulfonyl-group; R₄ hydrogen atom or C₁-C₄-alkyl, and n 0 or 1; or R₂ a group of the formula (II) their enantiomers with asymmetric center, their acid-additive pharmaceutically acceptable salts and pharmaceutical composition on their basis. EFFECT: improved method of synthesis. 3 cl