ETHYL AND 3-(N,N-DIMETHYLAMINO)-2,2-DIMETHYPROPYL DIESTER OF 2,5-DIMETHYL-4-(3-NITROPHENYL)-1,4- DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID HYDROCHLORIDE SHOWING PROLONGED ANTIHYPERTENSION EFFECT

摘要

FIELD: organic chemistry. SUBSTANCE: product: ethyl and 3-(N,N-dimethylamino)- 2,2-dimethylpropyl diester of 2,5-dimethyl-4-(3-nitrophenyl)- 1,4-dihydropyrimidine-3,5-dica- rboxylic acid hydrochloride of the formula C₂₄H₃₃N₃₀O₆Cl, yield is 56% LD₅₀ 220 mg/kg (i. m. to white mouse). Reagent 1: 2,2-dimethyl-3-(N, N-dimethylamino)-propanol. Reagent 2: diketene. Reaction conditions: in ether medium, at temperature 25 C (not above), and 3-(N, N-dimethylamino)-2,2-dimethylpropyl ester of acetoacetic acid is isolated. Reagent 3: ammonia. Reaction conditions: in methanol, at temperature 10 C (not above), and 3-(N,N-dimethylamino-2,2-dimethylpropyl ester of 3-crotonic acid is isolated. Reagent 4: 2-(3-nitrobenzylidene)-acetoacetic acid ethyl ester. Reaction conditions: in anhydrous ether, and ethyl and 3-(N,N-dimethylamino)-2,2-dimethylpropyl diester of 2,5-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb- oxylic acid were isolated. Reagent 5: HCl. Reaction condition: in ether medium. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 dwg, 1 tbl