METHOD OF SYNTHESIS OF 5-AMINO-2,4,6-TRIIODO- 1,3-BENZOCARBOXYLIC ACID DERIVATIVES

摘要

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 5-amino-2,4,6-triiodo-1,3-benzocarboxylic acid of the formula (I) where y simple bond or -CH₂-CH₂-,CH₂-O,-OCH₂,-CH₂ or oxygen; R₁ and R₂ are different or similar group: HO-CH₂-CH(OH)-CH₂-;; [HOCH₂]CH;-(CH₂)₂OH;CH-CH₂(OH)-CH(CH₂OH)-; HO-CH₂-CH(OH)-CH(CH₂OH)-;R₃-R₄(3) and R hydrogen, methyl, ethoxyl; R₅-R₆ and R hydrogen, alkyl, hydroxyl, methoxyl, ethoxyl. Reagent 1: compounds of the formula (II) . Reaction conditions: cyclization of reagent 1. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 5 tbl