saccharomyces cerevisiae strain, which is a heterologes protein produced, and processes for producing the heterologous protein by fermentation of this tribe.

摘要

The invention relates to a new strain of Saccharomyces cerevisiae productive of a heterologous protein, and more especially of hirudin, characterized by a suppression of the proteolytic function encoded by the PRC1 gene. More specifically, this deficiency is due to a mutation or more especially to a deletion of the PRC1 structural gene.