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Converting an alcohol to an azide with S.sub.N 2 inversion using a phosphoryl azide
Converting an alcohol to an azide with S.sub.N 2 inversion using a phosphoryl azide
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机译:使用磷酰基叠氮化物通过SN 2转化将醇转化为叠氮化物
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摘要
Described is a process for converting an alcohol to an azide with S. sub.N 2 inversion using a phosphoryl azide, e.g. diphenylphosphoryl azide (DPPA). Good yields of azide in high enantiomeric excess can be achieved specifically for benzylic alcohols and alpha-hydroxy alkyl esters. The process is carried at preferably room temperature in an inert dry aprotic solvent, e.g. toluene, and in the presence of a proton acceptor, e.g. 1,8- diazabicyclo[5.4.0]undec-7-ene (DBU) to afford high yields of high enantiomeric purities.
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