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Methods and compositions for diagnosing HTLV-I associated myelopathy and adult T-cell leukemia
Methods and compositions for diagnosing HTLV-I associated myelopathy and adult T-cell leukemia
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机译:诊断HTLV-1相关性脊髓病和成人T细胞白血病的方法和组合物
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摘要
The invention provides antigenic peptides derived from immunodominant epitopes of the HTLV-I tax or rex proteins that are immunoreactive with antibodies associated with disease in HTLV-I infected subjects. More specifically, the invention provides antigenic peptides consisting essentially of the amino acid sequences defined in the sequence listing by SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7 and 8 and antigenic fragments thereof. The invention provides a method of diagnosing HTLV-I associated myelopathy (HAM) or a predisposition thereto, comprising the steps of: (a) contacting an antibody containing sample from the subject with a detectable amount of a peptide of the invention or an antigenic fragment thereof; and (b) detecting the reaction of the peptide with an antibody in the sample, the reaction indicating HTLV-I associated myelopathy or a predisposition thereto. The invention also provides a method of diagnosing adult T-cell leukemia or a predisposition thereto in a subject, comprising the steps of: (a) contacting an antibody containing sample from the subject with a detectable amount of the peptide of SEQ ID NO: 1; and (b) detecting the reaction of the peptide with an antibody in the sample, the reaction indicating adult T-cell leukemia or predisposition thereto.
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机译:本发明提供了来源于与HTLV-1感染的受试者中与疾病相关的抗体具有免疫反应性的HTLV-1tax或rex蛋白的免疫优势表位的抗原性肽。更具体地说,本发明提供了基本上由序列表中SEQ ID NO:1、2、3、4、5、6、7和8所定义的氨基酸序列组成的抗原肽及其抗原片段。本发明提供了一种诊断HTLV-1相关性脊髓病(HAM)或其易感性的方法,其包括以下步骤:(a)使来自受试者的含有抗体的样品与可检测量的本发明的肽或抗原性片段接触。其中(b)检测肽与样品中抗体的反应,该反应表明HTLV-1相关的脊髓病或其易感性。本发明还提供了在受试者中诊断成人T细胞白血病或其倾向的方法,其包括以下步骤:(a)使来自受试者的含有抗体的样品与可检测量的SEQ ID NO:1的肽接触。 ; (b)检测该肽与样品中抗体的反应,该反应表明成人T细胞白血病或其易感性。
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