Molecular cloning of antigens shared by rat- and human-derived Pneumocystis carinii

摘要

DNAs encoding antigens of mammalian, Pneumocystis carinii including the gp116 major surface antigen of rat and human P. carinii; P. carinii DNA containing homologous nucleotide sequences to the antigen encoding DNA; RNAs, proteins, monospecific antibodies and chimeric molecules derived from the DNAs; and probes and diagnostic methods, vaccine compositions and anti-P. carinii agents, and methods of treatment for and prophylaxis against P. carinii infection and pneumonitis are claimed.