Process for producing optically active halogen-containing alcohols using lipase ay-120 from Candida rugosa

摘要

A process for producing an optically active halogen-containing alcohol having a high optical purity and represented by the following formula [I] ##STR1## wherein R.sup.1 is a halogen substituted alkyl group, R.sup.2 is a group selected from the group consisting of a substituted or unsubstituted alkyl group, alkene group, or alkyne group, and a substituted or unsubstituted phenyl group, and C having an asterisk indicates an asymmetric atom,PPis disclosed which process comprises subjecting a halogenated alkyl ester of a carboxylic acid represented by the following formula [II] ##STR2## wherein R.sup.1 and R. sup.2 are the same as mentioned above and R.sup.3 is a group selected from the group consisting of a substituted or unsubstituted alkyl group or alkene group, and a substituted or unsabstituted phenyl group,P Pto asymmetric hydrolysis with an enzyme in an aqueous solution system, and the aqueous solution system may contain buffer solution and/or organic solvent.