Process for preparing protected -lactams n-carbamate optically active optical resolution by using a Candida antarctica lipase.

摘要

A method for generating a beta-lactam N-protected stereoisomerically pure from a mixture disastereómeros comprising contacting the mixture of beta-lactam N-protected comprising enantiomers according to structural formulas (1) and (2 .) ** ** see formula in which: a represents a monocyclic, polycyclic or polycyclic saturated or unsaturated ring bridge; and R is a carbamate or a protecting group thiocarbamate, with a lipase from Candida antarctica under conditions in which the lipase selectively cleaves enantiomer 2, thereby yielding a mixture of reaction products according to structural formulas 1 with and 4: see formula ** **