PURPOSE: To simply obtain a 1-hydroxyindole derivative, having suppressing actions on blood platelet agglutination and useful as an antiplatelet agent by oxidizing a 2,3-dihydroindole compound. ;CONSTITUTION: This compound of formula I [A is CH2N(-R), N(-R)CH2, etc.; R is an alkoxycarbonyl such as methoxycarbonyl or ethoxycarbonyl; (n) is an integer of 1-3], e.g. 9-hydroxy-1,2,3,4-tetrahydrocarbazole. The compound of formula I is obtained by dissolving a compound of formula II, e.g. 1,2,3,4,4a,9 a-hexahydrocarbazole in an inert organic solvent such as methanol and carrying out the oxidizing reaction using an oxidizing agent such as an organic peroxide, a metallic peroxide or persulfuric acid under stirring and cooling conditions with ice. In the process, sodium tungstate dihydrate in a molar amount of 0.2 based on the compound of formula II and an aqueous hydrogen peroxide in a molar amount of 10 times based on the compound of formula II are most preferred as the oxidizing agent.;COPYRIGHT: (C)1996,JPO
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