In epito - pu which supports possesses the immunity production property of the HBs antigen and by the HBs antigen the imported antigen region vectoring - for the grain and catches grain production which supports the constituent null for mixture vaccine production which contains the animal cell and the grain which catches

摘要

The invention relates to particles possessing the essential features of particles based on HBs antigen, these particles being formed from a major polypeptide characteristic of the HBs antigen into which has been incorporated a foreign polypeptide sequence provided with an immunogenic site different from those normally borne by the S gene. The invention also relates to recombinant DNAs coding for the major polypeptide transformed in the manner described above, and to cell lines transformed by this recombinant DNA and capable, in particular when the foreign amino acid sequence contains not more than 16 amino acids, of being excreted into the culture medium of the abovementioned cell line.