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Taxol, yew cultured tissue as an anti-cancer / anti-viral compound raw materials and other novel related taxane
Taxol, yew cultured tissue as an anti-cancer / anti-viral compound raw materials and other novel related taxane
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机译:紫杉醇,紫杉培养组织作为抗癌/抗病毒复合原料以及其他新型相关紫杉烷
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摘要
Successful culture methods have been developed which result in stable, long-term tissue cultures derived from Taxus explants and hydroponically grown roots. These cultures offer a rapidly reproducible, continuously-available source for the production of purified taxol and taxol-related compounds. Culture methods include in vitro tissue culture and hydroponics. Cultures are initiated with stem or root tissues of Taxus or from roots grown hydroponically. Taxol production may be scaled to commercial levels by use of bioreactors. Screening assays are provided for species and cultures of Taxus that are sources of taxol and taxol-related compounds. In addition to obtaining the same compositions as presently directly extracted from yew trees, new compositions exhibiting taxol-like activity, have been purified from the novel Taxus sources, offering new horizons for chemotherapeutic agent development.
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