Production method of 5,8-dihydro-naphthoquinone derivatives, the use of it as an anti-cancer agent and 5,8-dihydro-naphthoquinone derivative of the new

摘要

PCT No. PCT/KR94/00091 Sec. 371 Date Mar. 14, 1995 Sec. 102(e) Date Mar. 14, 1995 PCT Filed Jul. 13, 1994 PCT Pub. No. WO95/02572 PCT Pub. Date Jan. 26, 19955,8-dihydroxynaphthoquinone derivatives represented by the following general formula (IA): kenyl, R2a represents alkyl or a group -C(O)R wherein R represents alkyl, alkenyl, aryl, aralkyl or aralkenyl, which can be substituted or unsubstituted with one or more halogen(s), and R3 represents hydrogen or alkyl, provided that when R2a is a group -C(O)R and R3 is hydrogen, R1 is other than 3-methyl-2-butenyl; and when R2a represents methyl and R3 independently represents hydrogen or methyl, R1 is other than 3-methylbutyl. Processes for preparing 5,8-dihydroxynaphthoquinone derivatives are also provided.