首页> 外国专利> The stomach esophagus counterflow disease and in order to remedy other faults - (-) * the manner which uses the cisapride

The stomach esophagus counterflow disease and in order to remedy other faults - (-) * the manner which uses the cisapride

机译:胃食道逆流疾病和以纠正其他缺陷-(-)*使用西沙必利的方式

摘要

A composition comprising (-) cisapride, or a pharmaceutically acceptable salt thereof, wherein the composition is for eliciting an antiemetic effect in a human by administering an amount thereof sufficient to alleviate nausea and vomiting whilst being insufficient to cause adverse side-effects associated with the administration of racemic cisapride, or while achieving a higher bioavailability than achieved with racemic cisapride; or the composition is for treating a condition caused by gastrointestinal motility dysfunction in a human by administering an amount thereof sufficient to alleviate said condition whilst being insufficient to cause adverse side-effects associated with the administration of racemic cisapride, or while achieving a higher bioavailability than achieved with racemic cisapride, and wherein the (-)-cisapride or pharmaceutically acceptable salt thereof comprises at least 90% by weight of the total amount of cisapride in the composition.
机译:包含(-)西沙必利或其药学上可接受的盐的组合物,其中该组合物用于通过给药足以减轻恶心和呕吐而不足以引起与之相关的不良副作用的量来在人体内引起止吐作用。施用外消旋西沙必利,或在获得比外消旋西沙必利更高的生物利用度时;或该组合物用于治疗人的胃肠道运动功能障碍所引起的病症,其施用量足以缓解所述病症,但不足以引起与消旋西沙必利的施用相关的不良副作用,或与用外消旋西沙必利可得到的化合物,其中(-)-西沙必利或其药学上可接受的盐占组合物中西沙必利总量的至少90重量%。

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