Cationic protein in mammals with anti activity and lipopolysaccharide-binding

摘要

(57) compositions and methods for the diagnosis and treatment of diseases associated with coagulation and conditions relating to] SUMMARY lipopolysaccharide is provided. The composition poly homologous or identical (CAP18) cationic several proteins obtained from granulocytes in a mammal, including a (RNIP) fragments reactive nitrogen inhibiting peptides found at the carboxy terminus of CAP18, especially peptides are included. Polypeptide may be coupled to LPS, to inhibit activation of the LPS-mediated macrophage, can interfere with the coagulation cascade as well as in order to inhibit coagulation in the state and disseminated intravascular coagulation. Composition comprising a polypeptide in a suitable pharmaceutical carrier is also provided as well.