hidorokisamu Acid compound, the manufacturing method and the metal professional tear which contains this - ze inhibiter

摘要

The invention provides a series of novel hydroxamic acids of the formula I CHEM which are useful as inhibitors of metalloproteases such as endopeptidases and wherein R1 is a hydrophobic group, R2 and R3 are each an amino acid residue, n is 1 or 2, and A is a group of the formula:- -CHR4.CO.NH2 in which R4 is an amino acid residue. Also described are processes for the manufacture of the hydroxamic acids, pharmaceutically acceptable salts derived from the said acids and pharmaceutical compositions containing a said acid or salt.