PEPTIDES CONTAINING SEQUENCE OF PORPHYROMONAS GINGIVALIS TYPE II PILUS PROTEIN AND THEIR USES

摘要

PURPOSE: To obtain the subject new peptides for producing a composition for diagnosis of periodontal diseases, preventive vaccine and an antibody for preventing and treating periodontal disease and being a subunit protein fragment constituting type II pilus of Porphyromonas gingivalis. ;CONSTITUTION: These new peptides are peptides corresponding to a fragment derived from an amino acid sequence of 72KDa subunit protein constituting type II pilus of Porphyromonas gingivalis and comprising a fragment containing continuing 5-10C amino acid residues expressed by formulas I to III, etc., and are useful for producing a composition for diagnosis of periodontal disease, vaccine for preventing periodontal disease and an antibody for preventing and treating periodontal disease. These peptides are obtained by synthesizing by a liquid phase or solid phase synthetic method of peptides from the amino sequence of 72KDa subunit protein fragment derived from Porphyromonas gingivalis 0MZ409 strain.;COPYRIGHT: (C)1996,JPO