2 formation under professional star great in I Shank medicine

摘要

PURPOSE:To obtain the titled drug, containing a stable neolignan having formation accelerating action in place of unstable prostaglandin I2 having inhibitory action on blood platelet agglutination, etc., as an active ingredient and useful as a preventive agent against thrombosis, arteriosclerosis, etc. CONSTITUTION:A prostaglandin I2 formation accelerator containing at least one selected from the group consisting of neolignan derivatives expressed by the formula [R1 is H, -CH=CHCH2OR4 (R4 is H or lower alkanoyl) or -CH= CHCHO; R2 is H, -CH=CHCH2OR4 or -CH=CHCHO: R3 is H or lower alkanoyl] as an active ingredient. In use, the agent is administered together with a commonly used formulation carrier. The content of the active ingredient expressed by the formula is normally about 1-70wt.%, particularly 1-30wt.% in the total composition. The compound expressed by the formula is obtained by extracting and isolating from fruits of Phytolacca americana L.