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Non infection characteristic HIV particle and its use
Non infection characteristic HIV particle and its use
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机译:非感染性艾滋病毒颗粒及其用途
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摘要
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
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