buhuajienorido type differentiation induction medicine

摘要

PURPOSE: To provide the subject inducing agent comprising a compound having a bufadienolide structural formula, excellent in the leukemia cell differentiation- inducing activity, absorbability and persistence and useful as an antitumor agent, etc. ;CONSTITUTION: The objective inducing agent comprises a compound having an bufadienolide structural formula of formula I (R₁, R₂ are H hydroxyl group; R₃ is H, aliphatic acid residue, amino acid residue, saccharide residue) or formula II (R is H, acetyl) which has an ability to induce the differentiation of cells such as various leukemia cells.;COPYRIGHT: (C)1993,JPO&Japio