P33CDK2 AND P34CDC2 CELL CYLCE REGULATORY KINASE AND PEPTIDEINHIBITOR OF HUMAN PAPILLOMAVIRUS E7 CARCINOGENIC PROTEIN

摘要

Novel peptide and peptide mimetic ligands which act as inhibitors of p34cdc2 kinase, p33cdk2 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.