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Process of detecting an infection or inflammation site in an individual detectably labeled chemotactic peptide pharmaceutical preparation of the chemotactic peptide and therapeutic composition

机译:在趋化肽和治疗组合物的个体可检测标记的趋化肽药物制剂中检测感染或炎症部位的方法

摘要

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.
机译:发明领域本发明涉及通过向个体施用诊断或治疗有效量的可检测标记的,治疗性或治疗性缀合的个体来检测个体中感染或炎症的部位的方法以及用于治疗此类感染或炎症的方法。基本上在感染或发炎部位积累的趋化肽,所述趋化肽具有一般结构X-Y-Leu-Phe- [Z] n-W,其中:X是氨基保护基,Y是氨基酸残基,Z是间隔序列,n为0或1,W为标记或连接取代基。

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