TRANSGENIC RABBITS WHICH EXPRESS HUMAN PLASMINOGEN ACTIVATOR IN THE MILK OF THE FEMALES

摘要

The present Invention relates to the field of Genetic Engineering and Biotechnology,And specifically with the obtaining of transgenic animals.This Invention aims to obtain a Breed of Rabbits can produce a Foreign Protein (Human Tissue Plasminogen Activator)In the Milk of their females.Its Essence is,In The genome of a Breed of Rabbits has been modified through the introduction of a segment of deoxyribonucleic acid (DNA) which containsThe information necessary for the synthesis and secretion in milk is the Human Protein.Breeding animals were obtained by first and second generation for a New character,With which we obtained a stable line of Transgenic Rabbits.This line of transgenic animals could be of Great utility for Studies aimed at Deciphering the mechanisms of Secretion of PRoteinas the Milk of mammalsAs well as certain quantities of P is properly formed and active Human roteina for Analytical tests,As for Studies on the functioning of the various control elements that integrate the Transgene in different tissues and during theDifferent stages of the Life of the animal. !