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PROCESS FOR PREPARING TWO-CHAIN PEPTIDES BEING COUPLED WITH EACH OTHER BY DISULFIDE OF LACTAM BRIDGES

机译:内酰胺桥二硫化物制备彼此偶联的两链肽的方法

摘要

production method dvouu0159etu011bzcovu00fdch peptides or laktu00e1movu00fdmi united disulfide bridges, according to which a carrier shall be dvoufunku010dnu00edm ortogonu00e1lnu011b protected linkerem,the first and the second group gradually specifically odchru00e1nu00ed and on one of them weigh the first chain amino acids fmoc strategies peptide synthesis using boc protected side chain andthe other amino acids the second chain boc strategy peptide synthesis.after the completion of both chains, these links disulfidicku00fdmi or laktu00e1movu00fdmi bridges and dvouu0159etu011bzcovu00e9 peptides are separated from the solid substrate and transferred to the solution. and
机译:制备方法dvou u0159et u011bzcov u00fdch肽或lakt u00e1mov u00fdmi联合二硫键,根据该方法,载体应为dvoufunk u010dn u00edm或被托贡 u00e1ln u011b保护的连接子,第一和第二组逐渐被特别保护并在其中一个上权衡使用boc保护的侧链合成第一链氨基酸fmoc策略肽,而在第二个链上,另一个氨基酸权衡第二链boc策略肽合成。从固体底物中分离出u00e1mov u00fdmi桥和dvou u0159et u011bzcov u00e9肽并转移到溶液中。 r和

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