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Reagent is connected with method replaces difluoromethyl group to be the petite person's electrophilic group of Composite Attack
Reagent is connected with method replaces difluoromethyl group to be the petite person's electrophilic group of Composite Attack
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机译:试剂与方法连接取代二氟甲基为娇小人的亲电基团
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摘要
For grafting a substd.Difluoromethyl gp.The cpd. electrophilic to oneOn nucleophilic reactant, comprising: a fluorocarboxylic acid of (a) formula Ea-CF2-COOH, wherein Ea is the electrophilic atom or gp. at least partly adding salt by organic or inorganic cation ; (b) polar non-solute. Potentially-free part the content being present in different component (i.e. impurity) is at most, equal to half initial molar concn. of fluorocarboxylic acid. Equally claimed is the difluoromethylene gp. for includingA deriv.Synthesis: (i) with mentioned reagent react an electrophilic cpd. ; (ii), in 100-200 deg.C is heated mixture 1/2 hour to one day.
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