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OCTAHYDRO- OR HEXAHYDRO-1H-ISOINDOLES AND PHARMACEUTICAL COMPOSITIONS BASED THEREON
OCTAHYDRO- OR HEXAHYDRO-1H-ISOINDOLES AND PHARMACEUTICAL COMPOSITIONS BASED THEREON
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机译:八面体或六面体-1H-异吲哚及其所基于的药物成分
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摘要
The 4-arylisoindoles of the formula (I)are effective analgesics including stereoisomers and pharmaceutically acceptable salts thereof, wherein (II) is (III), (IV) or (V); with the proviso that there is 0 or 1 unsaturated bond in the isoindole ring and with the proviso that where the stereoisomer is: a) the 3a beta , 4 beta , 7a alpha diastereomer, then a double bond joins the 5- and 6-position carbons or the 6- and 7-position carbons; b) the 3a beta , 4 alpha , 7a alpha or the 3a beta , 4 alpha , 7a beta diastereomers, then the double bond joins the 5- and 6-position carbons; and c) the 3a beta , 4 beta , 7a beta diastereomer, then the double bond joins the 6- and 7-position carbons.
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