ADDITION SALT OF 3-/2-/4-(6-FLUORO-1,2-BENZOISOXAZOL-3-YL(-PIPERIDYL/ETHYL/-6,7,8,9- -TETRAHYDRO-2-METHYL-4H-PYRIDO /1,2-a/PYRIMIDIN-4-ONE WITH PAMOIC ACID PER SE AND FOR USE IN MEDICINE, PROCESS OF ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS BASED THEREON AND PROCESS OF THEIR PREPARATION

摘要

In the present invention there are disclosed an addition salt of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, usually known under name of risperidone with pamoic acid, of the general formula I as a novel substance and intended for use as a medicament, further a process for preparing the above specified salt, which preparation process is characterized in that 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is treated with pamoic acid in a solvent being inert with respect to this reaction. In the present invention there is also claimed a pharmaceutical preparation based on this salt.