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Process for the preparation of the microcapsule, which in extended release of luteinizing hormone-releasing hormone
Process for the preparation of the microcapsule, which in extended release of luteinizing hormone-releasing hormone
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机译:制备微胶囊的方法,其可延长黄体生成素释放激素的释放
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摘要
This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, the molar composition ratio of lactic acid/glycolic acid being 80/20 to 100/0, subjecting said water-in oil emulsion to microencapsulation.
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