CHELATE SUBSTANCES FOR TARGETED DELIVERY OF GROWTH FACTORS FOR BONE REGENERATION, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

Specific target delivery composition systems where growth factors are linked, optionally using an acid cleavable linker, to a polyaminomethylenephosphonic acid ligand and are especially suitable for site delivery to bone. When the acid cleavable linker is present, the composition is activated for the growth factors at the bone site while it remains inactive while circulating in the body. Process to make the compound and composition are also taught.