PHARMACEUTICAL COMPOSITIONS INHIBITING SMOOTH MUSCLE CELL PROLIFERATION AND RESTINOSIS CONTAINING 2-PHENYL-3-AROYL-BENZOTIOPHENE- AND 2-PHENYL-3-AROYL-NAPHTALENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

摘要

Methods of inhibiting smooth muscle cell proliferation and restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula CHEM or CHEM wherein R1 and R3 are independently hydrogen, -CH3, CHEM or CHEM wherein Ar is optionally substituted phenyl; R2 is CHEM and R4 is hydrogen or -OR1, and pharmaceutically acceptable salts and solvates thereof. Also provided is a method for inhibiting restinosis.