USE OF3-(4-AZEPINO, -PYRROLIDINO AND -PIPERIDINOETHOXYBENZOYL)-2-(4-HYDROXYPHENYL)-7-HYDROXYBENZOTHIOPHENE DERIVATIVES AND THE CORRESPONDING DIHYDRONAPHTHALENE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS FOR THE INHIBITION OF SMOOTH MUSCLE CELL PROLIFERATION OR OF RESTINOSIS

摘要

Methods of inhibiting smooth muscle cell proliferation and restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula CHEM or CHEM wherein R1 and R3 are independently hydrogen, -CH3, CHEM or CHEM wherein Ar is optionally substituted phenyl; R2 is CHEM and R4 is hydrogen or -OR1, and pharmaceutically acceptable salts and solvates thereof. Also provided is a method for inhibiting restinosis.