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Polyamines useful as antagonists of excitatory ami no acid neurotransmitters and/or as blockers of calcium channels
Polyamines useful as antagonists of excitatory ami no acid neurotransmitters and/or as blockers of calcium channels
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机译:多胺可用作兴奋性氨基酸酸性神经递质的拮抗剂和/或钙通道阻滞剂
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摘要
This invention relates to certain polyamines and polypeptides found to be present in the venom of the Agelenopsis aperta spider. The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests. The polypeptides of this invention and one of said polyamines and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel mediated diseases and conditions and in the control of invertebrate pests. This invention also relates to compositions comprising said polyamines, polypeptides and salts thereof.
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