Substituted alkyl 1-phenylalkyl-4-hydroxy-2-oxo- 1,8-naphthyridine-3-carboxylates their preparation and therapeutic compositions containing them

摘要

PCT No. PCT/EP95/03808 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Sep. 26, 1995 PCT Pub. No. WO96/11199 PCT Pub. Date Apr. 18, 1996Compounds of formula I IMAGE I including pharmaceutically acceptable salts thereof in which R1 represents a phenyl C1-6 alkyl group (in which the phenyl ring is optionally substituted by one or more of the following: halo, a C1-4 alkyl group, a C1-4 alkoxy group, hydroxy or trifluoromethyl) and the alkyl chain is optionally substituted by one or more C1-2 alkyl groups; R2 represents a C2-6 alkoxycarbonyl group; and R3 represents hydrogen or halo are disclosed, which are antirheumatic agents and are useful as modulators of cytokine synthesis, immunomodulatory agents, antiinflammatory agents and anti-allergic agents. Compositions containing these compounds and processes to make these compounds are also disclosed.