process for preparation of compounds of the enzyme lp - pla2 inhibitors, pharmaceutical compositions containing them, and

摘要

PCT No. PCT/EP95/05130 Sec. 371 Date Nov. 21, 1997 Sec. 102(e) Date Nov. 21, 1997 PCT Filed Dec. 20, 1995 PCT Pub. No. WO96/19451 PCT Pub. Date Jun. 27, 1996Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C(1-8)alkyl; R3 is aryl or aryl C(1-4)alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis.