(20S)-16ALPHA,17ALPHA-METHYLENEDIOXY-11BETA-HYDROXY-17BETA-( SULPHUR SUBSTITUTED)ANDROST- -AN-3-ONE OR -EN-3-ONE DERIVATIVES

摘要

Compounds of formula I IMAGE formula I where R1, R2, R3, R4, R5, R6, n, and +Z are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical compositions comprising them, and methods for their preparation comprising irradiating compounds of formula II IMAGE formula II under an inert atmosphere, in the presence or absence of a compound of formula R3-S-S(O)m-R8, where R7, R8, and m are as defined herein, and methods for their preparation comprising oxidizing, reducing, halogenating, or alkylating compounds of formula I are disclosed.