1-OXO-1,2-DIHYDROISOQUINOLINOYLGUANIDINES AND 1,1-DIOXO-2H-1,2-BENZOTHIAZINOYLGUANIDINE DERIVATIVES; MEDICAMENTS, USE AS DIAGNOSTIC AGENTS AND INTERMEDIATES

摘要

There are described acylguanidines I IMAGE where X is carbonyl or sulphonyl; R(1) is H, (cyclo)alkyl, phenyl; R(2) is H, alkyl, and their pharmaceutically tolerable salts. They are obtained by reaction of a compound II IMAGE with guanidine. The compounds have no undesired salidiuretic properties, but have very good antiarrhythmic properties. As a result of inhibition of the cellular Na+/H+ exchange mechanism, they can be used for the treatment of all acute or chronic injuries induced by ischaemia.