The compound pharmaceutical formulation, a process for preparing a sulfonimidamida and sulfonimidamida obtained

摘要

This invention provides certain novel sulfonimidamide compounds CHEM wherein R1 is CHEM wherein A, B and C are as defined in claim 1; R2 is H, C1-C8 alkyl with the proviso that except for the isopropyl group there is no branching in the alpha-position, C3-C8 alkenyl, -(CH2)nOH wherein n is 1-5, -(CH2)pC6H5 wherein p is 1-3, or -C(O)Rd wherein Rdis H or C1-C4 alkyl; R3 is H or -CH3; Z is -C(O)NR4R5 or -C(OR6)=NR5 wherein R4 is H or -CH3; R5 is CHEM wherein X is chlorine, bromine, iodine or -CH3; R6 is -C(O)Ra or a tautomer or pharmaceutically acceptable salt thereof. In addition, this invention encompasses formulations employing, processes of preparing, and methods of using these compounds as antineoplastic agents.