BACTERIA THAT HOST VECTOR OF EXPRESSION THAT CODES THE HUMAN CILIAR NEUROTROPHIC FACTOR (H-CNTF), ITS USE IN THE PRODUCTION OF H-CNTF, ANTIBODIES FOR H-CNTF AND THE USE OF H-CNTF IN MEDICAL TREATMENT.

摘要

THE INVENTION REFERS TO NUCLEIC ACID SEQUENCES CODING A CILIARY NEUROTROPHIC FACTOR (CNTF) AND TO PROTEINS, PEPTIDES AND DERIVATIVES PRODUCED FROM THEM. IN SEVERAL APPLICATIONS OF THE INVENTION, NUCLEIC ACID SEQUENCES, PROTEINS AND PEPTIDES OF THE INVENTION MAY BE USED IN THE TREATMENT OF SEVERAL NEUROLOGICAL DISEASES AND DISORDERS, INCLUDING ALZHEIMER DISEASE. IN A SPECIFIC APPLICATION OF THE INVENTION, THE CNTF MAY BE USED TO SUPPORT THE GROWTH OF SPINAL CORD NEURONS, THEREFORE PROVIDING A METHOD FOR THE TREATMENT OF EVILS IN THE SPINAL CORD, NUTRITIONAL, DEFICIENT, OR . THE INVENTION ALSO REFERS TO A NEW METHOD FOR PRODUCING A SUBSTANTIALLY PURE CNTF. THE INVENTION ALSO REFERS TO PHARMACEUTICAL COMPOUNDS CONTAINING EFFECTIVE AMOUNTS OF CNTF GENE PRODUCTS THAT MAY BE USED IN THE DIAGNOSIS AND TREATMENT OF VARIOUS NEUROLOGICAL DISEASES AND DISORDERS. THE INVENTION IS RELATED TO SEQUENTIAL CONTROL CLONING AND EXPRESSION OF CNTF AND PROVIDES, FOR THE FIRST TIME, A MEANS TO PRODUCE A HUMAN CNTF USING NUCLEIC ACID SEQUENCES CODING A HUMAN CNTF. FURTHER, THE NUCLEIC ACID SEQUENCES OF THE CNTF OF THE INVENTION MAY BE USED TO IDENTIFY NUCLEIC ACID SEQUENCES CODING THE CNTF OR HOMOLOGICAL MOLECULES OF THE CNTF IN A WIDE VARIETY OF SPECIES AND TISSUES.