BIOLOGICALLY STABLE POLYMER CONJUGATES AND POLYNUCLEOTIDES TO TREAT SYSTEMIC LUPUS ERITEMATOSO.

摘要

CHEMICALLY DEFINED CONJUGATES OF BIOLOGICALLY STABLE POLYMERS, SUCH AS D-GLUTAMIC AND LYSINE-D ACID POLYMERS, AND POLYNUCLEOTIDE DUPLICATIONS OF AT LEAST 20 BASE PARTIES OF THE ANTI-MANUFACTURERS OF THE ANTI-SELF-ASSEMBLIES . DUPLICATIONS ARE PREFERABLY HOMOGENEOUS IN LENGTH AND STRUCTURE AND ARE LINKED TO THE POLYMER THROUGH REACTION IN AN AMINOREACTIVE FUNCTIONAL GROUP LOCATED IN OR NEAR THE END OF EACH DUPLICATION. THESE CONJUGATES ARE TOLEROGENS FOR MAN'S SYSTEMIC Erythematous LUPUS.