CONJUGATES OF BIOLOGICALLY STABLE POLYMERS AND POLYNUCLEOTIDES FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS

摘要

Chemically defined conjugates of biologicallystable polymers, such as copolymers of D-glutamic acid andD-lysine, and polynucleotide duplexes of at least 20 basepairs that have significant binding activity for humanlupus anti-dsDNA autoantibodies. The duplexes are prefer-ably homogeneous in length and structure and are bound tothe polymer via reaction between an amino-reactivefunctional group located at or proximate a terminus ofeach duplex. These conjugates are tolerogens for humansystemic lupus erythematosus.