A 2-[2-(indol-3-yl)ethylamino]-1-phenylethanol derivative represented by general formula (I) and a pharmaceutically acceptable acid-addition salt thereof, wherein R1 stands for halogen or trifluoromethyl; R2 stands for hydrogen, lower alkyl or fluorinated lower alkyl; and R3 stands for hydrogen, halogen, trifluoromethyl, nitro or cyano. This compound has a highly selective activity of stimulating beta 3 adrenaline receptors and is usable for treating or preventing diabetes, obesity, irritable bowel syndrome, acute or chronic diarrhea and so forth, and also for ameliorating syndromes accompanying peptic ulcer, acute or chronic gastritis, and so forth, such as abdominal pain, nausea, vomiting and epigastric discomfort.
展开▼
机译:通式(I)表示的2- [2-(吲哚-3-基)乙基氨基] -1-苯基乙醇衍生物及其药学上可接受的酸加成盐,其中R1代表卤素或三氟甲基; R 2代表氢,低级烷基或氟化的低级烷基; R 3代表氢,卤素,三氟甲基,硝基或氰基。该化合物具有刺激β3肾上腺素受体的高度选择性活性,可用于治疗或预防糖尿病,肥胖症,肠易激综合征,急性或慢性腹泻等,也可用于缓解消化性溃疡,急性或慢性胃炎等伴随的综合征,诸如腹痛,恶心,呕吐和上腹部不适等。
展开▼