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substituted 2- 2- (phenyl) ethylamino alkanamide derivatives and their use as sodium and / or calcium channel modulators

机译:取代的2- [2-(苯基)乙基氨基]烷酰胺衍生物及其作为钠和/或钙通道调节剂的用途

摘要

substituted 2- [2- (phenyl) ethylamino] alkanamide derivatives and their use as sodium and / or calcium channel modulators the present invention relates to substituted 2- [2- (phenyl) ethylamino] alkanamide derivatives of formula wherein x, y, z, r, r1, r2, r3, r'3 r4, r5, r6, r7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use. as sodium and / or calcium channel modulators useful in preventing, relieving and curing a wide range of conditions, including but not limited to neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal disorders, where the above mechanisms have been described. as playing a pathological role.
机译:取代的2- [2-(苯基)乙基氨基]烷酰胺衍生物及其作为钠和/或钙通道调节剂的用途本发明涉及下式的取代的2- [2-(苯基)乙基氨基]烷酰胺衍生物,其中x,y,z R 1,r 1,r 2,r 3,r′3 r 4,r 5,r 6,r 7具有说明书中定义的含义及其药学上可接受的盐,包含它们作为活性成分的药物组合物及其用途。作为钠和/或钙通道调节剂,可用于预防,缓解和治愈各种疾病,包括但不限于神经,认知,精神病,炎症,泌尿生殖系统和胃肠道疾病,其中已描述了上述机制。扮演病理角色。

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