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Method of controlling ph in the vicinity of biodegradable implants, and method of increasing surface porosity

机译:控制可生物降解植入物附近的ph值的方法以及增加表面孔隙率的方法

摘要

The invention discloses pH-controlling devices that comprise a biodegradable polymer and a pH-controlling substance, particularly an alkaline, acidic or buffering agents. By way of example, such alkaline agents include calcium carbonate and sodium bicarbonate. Methods of preparing such devices are also described. Methods for enhancing biocompatibility of an implantable device are also provided, as neutralizing alkaline materials are released at a rate that offsets changes in pH typically observed as polymers degrade to various acidic or alkaline by-products. By way of example, biodegradable polymers include PLA, PGA, polycaprolactone, copolymers thereof, or mixtures thereof. A new technique is disclosed to increase the surface porosity of porous implants which have a tendency to form relatively impermeable coverings. This technique entails the use of mechanical means to remove at least part of said covering, thus increasing the implant's surface porosity and permeability.
机译:本发明公开了一种pH控制装置,其包括可生物降解的聚合物和pH控制物质,特别是碱性,酸性或缓冲剂。举例来说,这种碱性剂包括碳酸钙和碳酸氢钠。还描述了制备这种装置的方法。还提供了用于增强可植入装置的生物相容性的方法,因为中和碱性物质的释放速率抵消了通常在聚合物降解为各种酸性或碱性副产物时观察到的pH值变化。举例来说,可生物降解的聚合物包括PLA,PGA,聚己内酯,其共聚物或它们的混合物。公开了一种新技术来增加具有形成相对不可渗透的覆盖物的趋势的多孔植入物的表面孔隙率。该技术需要使用机械手段来去除至少一部分所述覆盖物,从而增加植入物的表面孔隙率和渗透性。

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