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INHIBITION OF HUMAN XENOGENIC OR ALLOGENIC ANTIBODIES TO REDUCE XENOGRAFT OR ALLOGRAFT REJECTION IN HUMAN RECIPIENTS
INHIBITION OF HUMAN XENOGENIC OR ALLOGENIC ANTIBODIES TO REDUCE XENOGRAFT OR ALLOGRAFT REJECTION IN HUMAN RECIPIENTS
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机译:抑制人类异种或同种异体抗体以减少人类受体的异种或异体移植排斥
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摘要
Reactivity between an alloantigen and an anti-alloantigen is indicative of immunological reactivity between two biological samples of the same species. Reactivity between a xenoantigen and an anti-xenoantigen is indicative of immunological reactivity between two biological samples of different species. In many cases both of the reactions are indicative of an antibody-mediated rejection. Anti-antibodies can be employed to reduce cross-reactivity in many transplantation-type situations, either within a similar species, or across species lines. These anti-antibodies are prepared against the antibodies responsible for the antibody-mediated rejection. These anti-antibodies can then be used in vivo or in vitro to complex with the antibodies thus reducing or eliminating reactivity between an alloantigen and an anti-alloantigen or reactivity between a xenoantigen and an anti-xenoantigen between any two species combinations. These antibodies may also be used to target and eliminate the B-cells that produce anti-xenogenic antibodies.
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