CHARACTERIZATION OF IMMUNE RESPONSES TO CARDIAC SELF-ANTIGENS MYOSIN AND VIMENTIN IN HUMAN CARDIAC ALLOGRAFT RECIPIENTS WITH ANTIBODY MEDIATED REJECTION AND CARDIAC ALLOGRAFT VASCUOLPATHY

摘要

BackgroundThe role of donor specific antibodies (DSA) to mismatched human leukocyte antigen (HLA) and antibodies (Abs) to cardiac self-antigens myosin (MYO) and vimentin (VIM) in the pathogenesis of acute antibody mediated rejection (AMR) in the early posttranplant period (EP,<12months) and cardiac allograft vasculopathy (CAV) in the late posttransplant period (LP,>12months) following heart transplantation (HTx) was studied.