ANTITHROMBOTIC AND NON-HEMORRHAGIC HEPARIN-BASED COMPOSITIONS, METHOD FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS

摘要

Heparin compositions having an antithrombotic activity and virtually no hemorrhagic activity. The object of the invention is to eliminate the risk of bleeding associated with heparins while retaining their main properties. The compositions of the invention (S1, S2, S3) therefore consist of heparin moieties such as those obtainable by the in vitro neutralization of a heparin with a protamine. The invention also concerns a method for the preparation of these compositions which are useful in preparing medicaments.