Antithrombotic and non-hemorrhagic heparin-based compositions, method for their preparation and therapeutic applications

摘要

PCT No. PCT/IB95/00405 Sec. 371 Date Feb. 18, 1997 Sec. 102(e) Date Feb. 18, 1997 PCT Filed May 29, 1995 PCT Pub. No. WO96/06623 PCT Pub. Date Mar. 7, 1996Heparin compositions having an antithrombotic activity and virtually no hemorrhagic activity are presented. The object of the invention is to eliminate the risk of bleeding associated with heparins while retaining their main properties. The compositions of the invention (S1, S2, S3) therefore consist of heparin moieties such as those obtainable by the in vitro neutralization of a heparin with a protamine. The invention also concerns a method for the preparation of these compositions which are useful in preparing medicaments.