TREATMENT OF KERATINIC AND PSORIATIC DISORDERS WITH A NAIL LACQUER CONTAINING A VITAMIN D METABOLITE OR DERIVATIVE AND/OR A VITAMIN A DERIVATIVE

摘要

Treatment of keratinic or psoriatic disorders prevailing in tissue under or surrounding nails with a pharmaceutical nail lacquer containing a therapeutically active vitamin D metabolite or a vitamin D derivative, or a vitamin A derivative, or a combination of such substances in a water insoluble film forming lacquer composition comprising an acrylic resin being a copolymerisate of acrylic acid esters and methacrylic acid esters, and a solvent system providing suitable characteristics with respect to viscosity, flow and spreading properties, short drying time, and satisfactory hardness, nail adhesion and durability of the dry lacquer film. Application to the nails once or twice a week allows the active substance(s) to penetrate into the keratinic tissue of the nail plate which acts as a depot for delivery of active substance(s) at therapeutically active concentrations to the nail bed, the nail matrix and nail surroundings.