Useful composition for the manufacture of vaccines containing particles bearing a hepatitis B virus surface antigen and polymerized human seric albumin receptor, animal cells able toproduce such particles and process for their obtention

摘要

Composition useful for producing vaccines containing particles having immunogenic properties characteristic of antigen HBsAg, said particles being more particularly characterized in that they also contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a gene of viral hepatitis B, said DNA sequence being placed under direct control of a promoter enabling the efficient transcription of said sequence in human or animal cells transformable by said vector.