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METHOD FOR THE DETECTION OF MOLECULES CONTAINING NUCLEOTIDIC MISMATCHES AND LOCATION THEREOF, AND APPLICATION TO DETECTION OF SUBSTITUTIONS OR DELETIONS OF BASES IN NUCLEOTIDIC SEQUENCES
METHOD FOR THE DETECTION OF MOLECULES CONTAINING NUCLEOTIDIC MISMATCHES AND LOCATION THEREOF, AND APPLICATION TO DETECTION OF SUBSTITUTIONS OR DELETIONS OF BASES IN NUCLEOTIDIC SEQUENCES
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机译:检测包含核酸错配的分子及其位置的方法,并应用于检测核酸序列中碱基的取代或缺失
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PCT No. PCT/FR94/01068 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Sep. 9, 1994 PCT Pub. No. WO95/07361 PCT Pub. Date Mar. 16, 1995Method for the detection and/or location of mutations or deletions in nucleotide sequences by creation of heteroduplexes between two types of double-stranded DNA able to form mismatches at the sites of said mutations or deletions. The heteroduplexes are detected as a result of the labeling of each type of strand by different fluorescent molecules or are screened by passage over a support which specifically retains them.
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